StudyPeer-reviewed research publisher
- Source type
- Study
- Access type
- Publisher
- Publisher
- New England Journal of Medicine
- Date
- 2022
- Added
- 2026-06-19
Trust profile
88
Peer-reviewed research publisher
- Publisher type
- Peer-reviewed journal
- Bias profile
- Moderate
Best used for
- Primary studies
- Systematic reviews
- Mechanistic research
Weak for
- Regulatory status
- Universal consumer recommendations
Used in Viral Vitalism
Primary sourcesignal3 references
GLP-1s Are Not Just a Weight Loss Story
Roles: Primary source
Primary sourcestudy1 reference
Tirzepatide once weekly for the treatment of obesity
Roles: Primary source
Show section-level references
Primary sourcetimeline1 reference
SURMOUNT-1
Roles: Primary source
Show section-level references
Claims supported
- Semaglutide and tirzepatide produce clinically meaningful average weight loss in studied adults with obesity or overweight, with results and tolerability varying by drug, dose, and patient context.
- Tirzepatide reduced body weight in adults with obesity or overweight in randomized clinical-trial populations.
- Public GLP-1 claims are distorted by both promotional hype and categorical backlash, neither of which substitutes for indication-specific evidence.
- Semaglutide and tirzepatide should not be collapsed into one generic claim because their mechanisms, labels, trial programs, and outcome evidence differ.
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- Trust score
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- Publisher
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- Access
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Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder
Trial registry for oral semaglutide among adults with AUD.
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Does Semaglutide Reduce Alcohol Intake
Trial registry for semaglutide and alcohol intake.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 1 connection
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Effects of Semaglutide on Nicotine Intake
Trial registry for semaglutide and nicotine intake.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 2 connections
Trial registryClinical trial registry
ESSENCE clinical trial registry
ClinicalTrials.gov used across the Viral Vitalism evidence library.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 3 connections
Trial registryGovernment health research
ESSENCE phase 3 trial design for semaglutide in MASH
PubMed used across the Viral Vitalism evidence library.
- Trust score
- 91
- Publisher
- PubMed
- Indexed by
- PubMed
- Access
- Abstract/index
- Usage
- 2 connections
Topic tags
glp-1tirzepatideobesityweight-losssurmount