StudyGovernment health research
- Source type
- Study
- Access type
- Full text
- Publisher
- JAMA Network Open / PubMed Central
- Date
- 2024
- Added
- 2026-06-19
Trust profile
91
Government health research
- Publisher type
- Government research
- Bias profile
- Low
Best used for
- Research synthesis
- Public-health context
- Safety resources
Weak for
- Primary endpoint extraction when a study is available
Used in Viral Vitalism
Primary sourcesignal3 references
GLP-1s, Dopamine, and Addiction: The Substance Use Signal
Roles: Primary source
Primary sourcestudy1 reference
Semaglutide and opioid overdose risk in patients with type 2 diabetes and opioid use disorder
Roles: Primary source
Show section-level references
Claims supported
- Observational studies report associations between GLP-1 use and several substance-use outcomes, but they cannot establish causality or treatment effectiveness.
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Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder
Trial registry for oral semaglutide among adults with AUD.
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- Publisher
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- Access
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- Usage
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Does Semaglutide Reduce Alcohol Intake
Trial registry for semaglutide and alcohol intake.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
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- Usage
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Trial registry for semaglutide and nicotine intake.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 2 connections
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ESSENCE clinical trial registry
ClinicalTrials.gov used across the Viral Vitalism evidence library.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 3 connections
Trial registryGovernment health research
ESSENCE phase 3 trial design for semaglutide in MASH
PubMed used across the Viral Vitalism evidence library.
- Trust score
- 91
- Publisher
- PubMed
- Indexed by
- PubMed
- Access
- Abstract/index
- Usage
- 2 connections
Topic tags
glp-1semaglutideopioid-use-disorderopioid-overdoseobservational