StudyGovernment health research
- Source type
- Study
- Access type
- Abstract/index
- Publisher
- The Lancet / PubMed
- Indexed by
- PubMed
- Date
- 2026
- Added
- 2026-06-19
Trust profile
91
Government health research
- Publisher type
- Government research
- Bias profile
- Low
Best used for
- Research synthesis
- Public-health context
- Safety resources
Weak for
- Primary endpoint extraction when a study is available
Used in Viral Vitalism
Primary sourcesignal9 references
GLP-1s, Dopamine, and Addiction: The Substance Use Signal
Roles: Primary source
Show section-level references
- Article source list
- Why this signal matters
- Alcohol has the strongest human signal
- The real-world alcohol data is compelling, but not causal
- Who might respond? That may be the real question
- Better consumer questions
- The bottom line
- Are GLP-1s approved to treat addiction or substance use disorder?
- Which substance has the strongest evidence so far?
Primary sourcestudy1 reference
Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity
Roles: Primary source
Show section-level references
Claims supported
- Early randomized human studies suggest GLP-1 receptor agonists may reduce some alcohol craving or drinking outcomes, but the evidence is not yet sufficient for routine addiction treatment.
Related studies
Related sources
GovernmentGovernment health research
GLP-1 plus therapy can reduce heavy drinking
NIH summary of semaglutide plus therapy trial for heavy drinking in AUD with obesity.
- Trust score
- 91
- Publisher
- NIH Research Matters
- Access
- Official
- Usage
- 3 connections
Trial registryClinical trial registry
Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder
Trial registry for oral semaglutide among adults with AUD.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 1 connection
Trial registryClinical trial registry
Does Semaglutide Reduce Alcohol Intake
Trial registry for semaglutide and alcohol intake.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 1 connection
Trial registryClinical trial registry
Semaglutide for Alcohol Use Disorder
Trial registry for early-phase semaglutide AUD trial.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 4 connections
Trial registryClinical trial registry
Semaglutide Therapy for Alcohol Reduction
Trial registry for semaglutide therapy for alcohol reduction.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 1 connection
Trial registryClinical trial registry
Effects of Semaglutide on Nicotine Intake
Trial registry for semaglutide and nicotine intake.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov
- Access
- Official
- Usage
- 2 connections
Topic tags
glp-1semaglutidealcohol-use-disorderobesity