Semaglutide and cardiovascular outcomes in obesity without diabetes

StudyPeer-reviewed research publisher

Source type: Study
Access type: Publisher
Publisher: New England Journal of Medicine
Date: 2023
Added: 2026-06-19

Trust profile

VV Source Trust Matrix v1.0

VV Source Trust Matrix v1.0 asks whether this source is trustworthy for the claim lane being used, not whether every possible claim from it is equally strong.

Peer-reviewed research publisher

Publisher type: Peer-reviewed journal
Bias profile: Moderate

This source is strongest for clinical outcomes and mechanism and weaker for regulatory status and trial discovery.

VV Source Fit Score 1.0

Fit by use case

Fit scores are role-specific. A source can be excellent for one claim lane and weak for another.

Frameworks ->

Regulatory status: 65/100; Context Source
Clinical outcomes: 92/100; Primary Anchor
Mechanism: 90/100; Primary Anchor
Safety: 86/100; Strong Support
Consumer context: 72/100; Context Source
Trial discovery: 65/100; Context Source

Best used for

Primary studies
Systematic reviews
Mechanistic research

Weak for

Regulatory status
Universal consumer recommendations

Used in Viral Vitalism

Primary sourcetimeline1 reference

SELECT

Roles: Primary source

Show section-level references

Cardiovascular outcomes data in adults with overweight or obesity and established cardiovascular disease without diabetes.

Primary sourcesignal3 references

GLP-1s Are Not Just a Weight Loss Story

Roles: Primary source

Show section-level references

Primary sourcestudy1 reference

Roles: Primary source

Show section-level references

SELECT

Claim ledger

Claims supported

Reviewed claim cards that cite this source in the evidence graph.

supported84/100

semaglutide: Semaglutide reduced major adverse cardiovascular events in SELECT participants

Semaglutide reduced major adverse cardiovascular events in SELECT participants with overweight or obesity and established cardiovascular disease without diabetes.

Strong human evidence3 sources

supported85/100