Mayo Clinic: Adrenal fatigue, what causes it?

Clinical resourceProfessional clinical guidance

Source type: Clinical resource
Access type: Publisher
Publisher: Mayo Clinic
Added: 2026-07-01

Trust profile

VV Source Trust Matrix v1.0

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Professional clinical guidance

Publisher type: Professional guidance
Bias profile: Moderate

This source is strongest for safety and consumer context and weaker for mechanism and trial discovery.

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Regulatory status: 63/100; Context Source
Clinical outcomes: 78/100; Strong Support
Mechanism: 63/100; Context Source
Safety: 86/100; Strong Support
Consumer context: 82/100; Strong Support
Trial discovery: 63/100; Context Source

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Replacing primary evidence

Used in Viral Vitalism

Supporting evidencesignal7 references

Cortisol Is Real. The Internet Turned It Into a Boogeyman.

Roles: Supporting evidence

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Supporting evidencestudy1 reference

Roles: Supporting evidence

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Mayo Clinic: Adrenal fatigue, what causes it?

Claim ledger

Claims supported

Reviewed claim cards that cite this source in the evidence graph.

partly supported85/100

adrenal fatigue: Adrenal fatigue is not a recognized medical diagnosis, and

Adrenal fatigue is not a recognized medical diagnosis, and vague symptoms should not be treated as proof that the adrenal glands are exhausted.

Expert context3 sources

uncertain78/100

cortisol: Routine cortisol testing for vague wellness symptoms can mislead

Routine cortisol testing for vague wellness symptoms can mislead when it is not tied to a validated clinical question, timing protocol, and differential diagnosis.

Expert context3 sources

unsupported56/100