StudyGovernment health research
- Source type
- Study
- Access type
- Abstract/index
- Publisher
- Obesity
- Indexed by
- PubMed
- Date
- 2016
- Added
- 2026-06-27
Trust profile
91
Government health research
- Publisher type
- Government research
- Bias profile
- Low
Best used for
- Research synthesis
- Public-health context
- Safety resources
Weak for
- Primary endpoint extraction when a study is available
Used in Viral Vitalism
Primary sourcesignal2 references
Calories Are the Accounting System, Not the Whole Metabolic Story
Roles: Primary source
Show section-level references
Primary sourcestudy1 reference
Persistent metabolic adaptation 6 years after The Biggest Loser competition
Roles: Primary source
Show section-level references
Claims supported
- Calories describe the accounting of tissue-energy change, but they do not explain all biological friction around appetite, expenditure, adaptation, food environment, hormones, sleep, lean mass, and maintenance.
- Large weight loss can reduce resting energy expenditure beyond what body-size change alone predicts, illustrating that calories-out is adaptive rather than fixed.
Related studies
Related sources
Trial registryClinical trial registry
SURMOUNT-MMO trial registry: tirzepatide and morbidity/mortality in obesity
ClinicalTrials.gov / Lilly Trial Registry used across the Viral Vitalism evidence library.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov / Lilly Trial Registry
- Access
- Publisher
- Usage
- 3 connections
GovernmentGovernment health research
NIDDK: Choosing a Safe & Successful Weight-loss Program
National Institute of Diabetes and Digestive and Kidney Diseases used across the Viral Vitalism evidence library.
- Trust score
- 91
- Publisher
- National Institute of Diabetes and Digestive and Kidney Diseases
- Access
- Official
- Usage
- 9 connections
GovernmentGovernment health research
CDC: Steps for Losing Weight
Centers for Disease Control and Prevention used across the Viral Vitalism evidence library.
- Trust score
- 91
- Publisher
- Centers for Disease Control and Prevention
- Access
- Official
- Usage
- 7 connections
GovernmentU.S. health regulator
FDA approves Wegovy to reduce risk of serious heart problems in adults with obesity or overweight and cardiovascular disease
U.S. Food and Drug Administration used across the Viral Vitalism evidence library.
- Trust score
- 94
- Publisher
- U.S. Food and Drug Administration
- Access
- Official
- Usage
- 6 connections
GovernmentU.S. health regulator
FDA approves Zepbound as first medication for obstructive sleep apnea in adults with obesity
U.S. Food and Drug Administration used across the Viral Vitalism evidence library.
- Trust score
- 94
- Publisher
- U.S. Food and Drug Administration
- Access
- Official
- Usage
- 6 connections
GovernmentU.S. health regulator
FDA's concerns with unapproved GLP-1 drugs used for weight loss
U.S. Food and Drug Administration used across the Viral Vitalism evidence library.
- Trust score
- 94
- Publisher
- U.S. Food and Drug Administration
- Access
- Official
- Usage
- 4 connections
Topic tags
weight-lossmetabolic-adaptationenergy-expenditureobesityweight-regainmaintenance