- Source type
- Study
- Access type
- Abstract/index
- Publisher
- Obesity
- Indexed by
- PubMed
- Date
- 2016
- Added
- 2026-06-27
Trust profile
VV Source Trust Matrix v1.0
VV Source Trust Matrix v1.0 asks whether this source is trustworthy for the claim lane being used, not whether every possible claim from it is equally strong.
91
Government health research
- Publisher type
- Government research
- Bias profile
- Low
This source is strongest for safety and clinical outcomes and weaker for consumer context and regulatory status.
VV Source Fit Score 1.0
Fit by use case
Fit scores are role-specific. A source can be excellent for one claim lane and weak for another.
- Regulatory status
- 66/100
- Context Source
- Clinical outcomes
- 90/100
- Primary Anchor
- Mechanism
- 90/100
- Primary Anchor
- Safety
- 92/100
- Primary Anchor
- Consumer context
- 88/100
- Strong Support
- Trial discovery
- 89/100
- Strong Support
Best used for
- Research synthesis
- Public-health context
- Safety resources
Weak for
- Primary endpoint extraction when a study is available
Used in Viral Vitalism
Calories Are the Accounting System, Not the Whole Metabolic Story
Roles: Primary source
Show section-level references
Persistent metabolic adaptation 6 years after The Biggest Loser competition
Roles: Primary source
Show section-level references
Claim ledger
Claims supported
Reviewed claim cards that cite this source in the evidence graph.
weight loss: Calories describe the accounting of tissue-energy change, but they
Calories describe the accounting of tissue-energy change, but they do not explain all biological friction around appetite, expenditure, adaptation, food environment, hormones, sleep, lean mass, and maintenance.
weight loss: Large weight loss can reduce resting energy expenditure beyond
Large weight loss can reduce resting energy expenditure beyond what body-size change alone predicts, illustrating that calories-out is adaptive rather than fixed.
Related studies
Related sources
SURMOUNT-MMO trial registry: tirzepatide and morbidity/mortality in obesity
ClinicalTrials.gov / Lilly Trial Registry used across the Viral Vitalism evidence library.
- Trust score
- 84
- Publisher
- ClinicalTrials.gov / Lilly Trial Registry
- Access
- Publisher
- Usage
- 3 connections
NIDDK: Choosing a Safe & Successful Weight-loss Program
National Institute of Diabetes and Digestive and Kidney Diseases used across the Viral Vitalism evidence library.
- Trust score
- 91
- Publisher
- National Institute of Diabetes and Digestive and Kidney Diseases
- Access
- Official
- Usage
- 9 connections
CDC: Steps for Losing Weight
Centers for Disease Control and Prevention used across the Viral Vitalism evidence library.
- Trust score
- 91
- Publisher
- Centers for Disease Control and Prevention
- Access
- Official
- Usage
- 7 connections
CMS: Medicare GLP-1 Bridge launch announcement
Primary CMS source for the temporary Medicare GLP-1 Bridge access program.
- Trust score
- 91
- Publisher
- Centers for Medicare & Medicaid Services
- Access
- Official
- Usage
- 1 connection
CMS: Medicare GLP-1 Bridge program page
Program details and eligibility context for Medicare GLP-1 Bridge.
- Trust score
- 91
- Publisher
- Centers for Medicare & Medicaid Services
- Access
- Official
- Usage
- 1 connection
FDA approves Wegovy to reduce risk of serious heart problems in adults with obesity or overweight and cardiovascular disease
U.S. Food and Drug Administration used across the Viral Vitalism evidence library.
- Trust score
- 94
- Publisher
- U.S. Food and Drug Administration
- Access
- Official
- Usage
- 6 connections